搜尋
國立成功大學醫學院附設醫院小兒科

PHYSICIAN

主治醫師

小兒感染科

Bird

何宗憲醫師

introduction

關於何宗憲醫師

Education

學歷  高雄醫學大學醫學士
成功大學微生物及免疫學 理學碩士
成功大學臨床醫學 醫學博士

校內外 、院內外之經歷:
衛生福利部臺南醫兒科主治醫師兼主任
成功大學醫學系小兒學科 臨床副教授
成功大學醫學系急診學科 臨床副教授
台灣兒童感染症醫學會 副秘書長
約翰霍普金斯大學公衛學院 訪問學者
成功大學醫學系急診學科 臨床講師
成大醫院急診部 主治醫師
成大醫院小兒部感染科 研究員
成大醫院小兒部 總醫師
成大醫院小兒部 住院醫師
校內、院內、部內職務 :
  • ✿ 成大醫院斗六分院副院長
  • ✿ 成大醫院小兒部 主治醫師
  • ✿ 成功大學醫學系小兒學科 臨床教授
校外與院外職務 :
  • ✿ 台灣急診醫學會兒童急診委員會 委員
  • ✿ 台灣急診醫學會感染防治委員會 委員
主要專長與次專科 :
  • ✿一般兒科學 (General Pediatrics)
  • ✿小兒感染症學 (Pediatric Infectious Diseases)
  • ✿兒童急診醫學 (Pediatric Emergency Medicine)
  • ✿兒童緩和醫療 (Pediatric Palliative Care)
  • ✿微生物免疫學 (Microbiology and Immunology)
專科證照 :
  • ✿ 小兒科專科醫師
  • ✿ 感染症專科醫師
  • ✿ 兒童高級救命術指導員
  • ✿ 兒童急診醫學專科醫師
  • ✿ 兒童重症醫學專科醫師
  • ✿ 安寧緩和醫學專科醫師
次專科 :
著作與歷年學術發表
 
​(A) Refereed Papers
1. Tsai CI, Chow NH, Ho TS and Lei HY. Intracerebral injection of myelin basic protein (MBP) induces inflammation in brain and causes paraplegia in MBP-sensitized B6 mice. 1997. Clinical and Experimental Immunology 109: 127-133. (SCI)
2. Ho TS, Tsai CY, Tsao N, Chow NH and Lei HY. 1997. Infiltrated cells in experimental allergic encephalomyelitis by additional intracerebral injection in myelin-basic-protein-sensitized B6 mice. Journal of Biomedical Science 4: 300-7. (SCI)
3. Wang SM, Ho TS, Shen CF and Liu CC. 2008. Enterovirus 71, one virus and many stories. Pediatrics and neonatology 49:113-5. (SCI)
4. 何宗憲, 王世敏, 柯文謙, 劉清泉. 2009. 兒童之困難梭狀桿菌相關疾病. 感染控制雜誌19:36-42.
5. Ho TS, Wang SM and Liu CC. 2010. Historical review of pandemic influenza A in Taiwan, 2009. Pediatrics and neonatology 51:83-8. (SCI)
6. Ho TS, Wang SM, Wu YH, Shen CF, Lin YJ, Lin CH and Liu CC. 2010. Long-term characteristics of healthcare-associated infections in a neonatal intensive care unit. Journal of Microbiology Immunology and Infection 43:407-15. (SCI)
7. Wang SM, Ho TS, Shen CF, Wang JR and Liu CC. 2011. Echovirus 18 meningitis in southern Taiwan. Pediatric Infectious Disease Journal 30: 259-60. (SCI)
8. Ho TS, Wang SM, Shen CF, Lee KH and Liu CC. 2011. Clinical Perspectives of Childhood Tuberculosis in Taiwan. Journal of the Formosan Medical Association 110:737-43. (SCI)
9. Ho TS, Wang SM, Wang LR and Liu CC. 2012. Changes in measles seroepidemiology of healthcare workers in southern Taiwan. Epidemiology and Infection 140:426-31. (SCI)
10. Shih HI, Ho TS, Chang CM, Hsu SC, Wang SM, Ko WC and Chi CH. 2012. Impacts of rapid flu clinic services at an emergency department during the pandemic flu season. American Journal of Infection Control 40:165-9. (SCI)
11. Wang SM, Ho TS, Lin HC, Lei HY, Wang JR and Liu CC. 2012. Reemerging of enterovirus 71 in Taiwan: The age impact on disease severity. European Journal of Clinical Microbiology & Infectious Diseases 31:1219-24. (SCI)
12. Lee KH, Ho TS, Shen CF, Wang SM, Ko WC and Liu CC. 2012. Clinical and laboratory characteristics among human immunodeficiency virus-infected adolescents: experience from the single medical center. Journal of Microbiology Immunology and Infection 45(5):329-36. (SCI)
13. Ho TS, Wang SM, Anderson R, Liu CC. 2013. Antibodies in dengue immunopathogenesis. Journal of the Formosan Medical Association 112(1):1-2. (SCI)
14. Ho TS, Huang MC, Wang SM, Hsu HC, Liu CC. 2013. Knowledge, attitude, and practice of dengue disease among healthcare professionals in southern Taiwan. Journal of the Formosan Medical Association 112(1):18-23. (SCI)
15. Shen CF, Wang SM, Lee KH, Ho TS, Liu CC. 2013. Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan. Journal of the Formosan Medical Association 112(9):561-568. (SCI)
16. Tai CH, Tsai YC, Wang CH, Ho TS, Chang CP, Lee GB. 2013. An integrated microfluidic platform for rapid detection and subtyping of influenza viruses from clinical samples. Microfluidics and Nanofluidics 16 (3), 501-512. (SCI)
17. Li X, Huang KJ, Ho TS, Liu CC, Lee YR, Lin CY, Shiuan D, Jiang XH. 2013. Monoclonal antibodies for diagnosis of enterovirus 71. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 32 (6), 386-394. (SCI)
18. Kan WM, Chao CS, Lin SJ, Chen CH, Feng JY, Lu FH, Lin PC, Ho TS. 2013. Thanatology for Medical College Students- Cultivation of Medical Humanity. Journal of Medical Education 17 (3), 97-106.
19. Ho TS, Wang SM, Lin YS, Liu CC. Clinical and laboratory predictive markers for acute dengue infection. 2013. Journal of Biomedical Science 20 (1), 75. (SCI)
20. Wang SM, Liao YT, Hu YS, Ho TS, Shen CF, Wang JR, Lin YS, Liu CC. 2014. Immunophenotype Expressions and Cytokine Profiles of Influenza A H1N1 Virus Infection in Pediatric Patients in 2009. Disease markers 2014:195453. (SCI)
21. Cho YH, Ho TS, Wang SM, Shen CF, Chuang PK, Liu CC. 2014. Childhood tuberculosis in southern Taiwan, with emphasis on central nervous system complications. J Microbiol Immunol Infect 47(6):503-11. (SCI)
22. Lee PH, Liu CM, Ho TS, Tsai YC, Lin CC, Wang YF, Chen YL, Yu CK, Wang SM, Liu CC, Shiau AL, Lei HY, Chang CP. 2015. Enterovirus 71 virion-associated galectin-1 facilitates viral replication and stability. PLoS One 10(2):e0116278. (SCI)
23. Cheng HJ, Luo YH, Wan SW, Lin CF, Wang ST, Hung NT, Liu CC, Ho TS, Liu HS, Yeh TM, Lin YS. 2015. Correlation between Serum Levels of Anti-Endothelial Cell Autoantigen and Anti-Dengue Virus Nonstructural Protein 1 Antibodies in Dengue Patients. Am J Trop Med Hyg 92(5):989-95. (SCI)
24. Shen CF, Wang SM, Ho TS, Liu CC. 2015. Reply to: "Serotype transition in invasive pneumococcal infection in postvaccine era". J Formos Med Assoc 114(8):787-8.
25. Kuo FC, Wang SM, Shen CF, Ma YJ, Ho TS, Chen JS, Cheng CN, Liu CC. 2017. Bloodstream infections in pediatric patients with acute leukemia: Emphasis on gram-negative bacteria infections. Journal of Microbiology Immunology and Infection 50(4):507-513.
26. CF Shen, SM Wang, TS Ho, CC Liu. 2017. Clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in Southern Taiwan: role of host immune response. BMC Infectious Diseases 17 (1), 196.
27. N Zainal, CP Chang, YL Cheng, YW Wu, R Anderson, SW Wan, CL Chen, TS Ho, S AbuBakar, YS Lin. 2017. Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection. Sci Rep. 2017; 7: 42998.
28. Lai YC, Chuang YC, Liu CC, Ho TS, Lin YS, Anderson R, Yeh TM. Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection. Sci Rep. 2017; 7(1):6975.
29. Chung N, Wang SM, Shen CF, Kuo FC, Ho TS, Hsiung CA, Mu JJ, Wu FT, Huang LM, Huang YC, et al. 2017. Clinical and epidemiological characteristics in hospitalized young children with acute gastroenteritis in southern Taiwan: According to major pathogens. Journal of Microbiology Immunology and Infection 50(6):915-922.
30. Wan SW, Chen PW, Chen CY, Lai YC, Chu YT, Hung CY, Lee H, Wu HF, Chuang YC, Lin J, Ho TS et al. 2017. Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection. J Immunol. 199(8):2834-2844.
31. Wu KW, Wang SM, Shen CF, Ho TS, Wang JR, Liu CC. 2018. Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan. Journal of Microbiology Immunology and Infection 51(6):749-755
32. Chen HR, Chao CH, Liu CC, Ho TS, Tsai HP, Perng GC, Lin YS, Wang JR, Yeh TM. Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability. PLoS Pathogens14(4):e1007033.
33. Wu PH*, Ho YL*, Ho TS*, Chang CH, Ye JC, Wang C., Sung HM, Huang HJ,  Liu CC. 2019. Microbial volatile compounds-induced cytotoxicity in the yeast Saccharomyces cerevisiae: The role of MAPK signaling and proteasome regulatory pathway. Chemosphere 233: 786-795. (*: These authors contribute equally to this work)
 
(B) Conference Papers (2008- )
1. Ho TS, Wang SM, Shen CF and Liu CC. Clinical manifestations and laboratory findings of enterovirus 71 infection in children in southern Taiwan. 2008. The 196th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
2. Ho TS, Wang SM, Shen CF and Liu CC. Comparison of clinical and laboratory findings between Dengue-infected adult and children in southern Taiwan. 2008. The 11th West Pacific Congress on Chemotherapy and Infectious Diseases. Taipei, Taiwan. (Oral presentation)
3. Shen CF, Ho TS, Wang SM and Liu CC. Changing patterns of antimicrobial resistance of invasive Streptococcus pneumoniae isolates from children in southern Taiwan. 2008. The 11th West Pacific Congress on Chemotherapy and Infectious Diseases. Taipei, Taiwan. (Poster presentation)
4. Ho TS, Wang SM, Shen CF and Liu CC. Acute flaccid paralysis due to non-osseous spinal tuberculosis in children. 2009. The 231st national case conference of the Infectious Diseases Society of Taiwan. Tainan, Taiwan. (Oral presentation)
5. Ho TS, Wang SM, Wu YH, Shen CF, Lin YJ, Lin CH and Liu CC. Long-term characteristics of nosocomial infection in a neonatal intensive care unit. 2009. The 2009 ID Advanced Forum, Infectious Diseases Society of Taiwan. Yilan, Taiwan. (Oral presentation)
6. Ho TS, Wang SM, Shen CF and Liu CC. Long-term characteristics of nosocomial infection in a neonatal intensive care unit. 2009. The 198th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
7. Yang MH, Ho TS, Shen CF, Wang SM and Liu CC. Longitudinal follow up of children born to human immunodeficiency virus infected mother in southern Taiwan: the impact of prophylaxis antiretroviral therapy on vertical transmission. 2009. The 198th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
8. Shen CF, Ho TS, Tsai HP, Kuo PH, Wang SM, Wang JR and Liu CC. Fecal viral excretion in children received live attenuated Oral presentation polio vaccine with prior inactivated poliovirus vaccination. 2009. The 198th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
9. Lee KH, Shen CF, Ho TS, Wang SM and Liu CC. Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae in children with invasive disease in southern Taiwan. 2009. The 200th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
10. Ho TS, Wang SM and Liu CC. Early clinical and laboratory features of dengue infection in Taiwan. 2009. Fourth Dengue Research Network Meeting. Singapore. (Poster presentation)
11. Yang CY, Ho TS, Wang SM and Liu CC. Pneumococcal arthritis and pyomyositis in a previously healthy infant. 2009. The 2009 Winter Meeting on Emergency Medicine, Taiwan Society of Emergency Medicine. Taichung, Taiwan. (Poster presentation)
12. Ho TS, Wang SM, Liu CC. Serological survey of measles immunity among healthcare workers in southern Taiwan, 2004-2009. 2010. The 2010 Annual Scientific Meeting of the Infectious Disease Society of Taiwan. Taipei, Taiwan. (Poster presentation)
13. Ho TS, Wang SM, Shen CF, Huang CY, Lin YJ, Lin CH and Liu CC. Antifungal susceptibility of bloodstream Candida isolates in a neonatal intensive care unit with routine fluconazole prophlaxis. 2010. The 6th Congress of Asian Society for Pediatric Research. Taipei, Taiwan. (Oral presentation)
14. Shen CF, Ho TS, Wang SM and Liu CC. Bacterial characteristics and immune activation of complicated pneumonia caused by Streptococcus pneumoniae in children. 2010. The 6th Congress of Asian Society for Pediatric Research. Taipei, Taiwan. (Oral presentation)
15. Ho TS, Wang SM, Wu YH, Shen CF and Liu CC. Healthcare-associated bloodstream infections in a neonatal intensive care unit in southern Taiwan. 2010. The 5th Asian Congress of Pediatric Infectious Diseases. Taipei, Taiwan. (Poster presentation)
16. Lee KH, Ho TS, Shen CF, Wang SM and Liu CC. Antimicrobial susceptibility and molecular characterization of Streptococcus pyogenes from children in southern Taiwan: trend of erythromycin resistance. 2010. The fifth Asian Congress of Pediatric Infectious Diseases. Taipei, Taiwan. (Oral presentation)
17. Cho YH, Lee KS, Shen CF, Ho TS, Wang SM and Liu CC. Pediatric extrapulmonary tuberculosis in southern Taiwan. 2010. The 204h Scientific Meeting of Taiwan Pediatric Association. Tainan, Taiwan. (Oral presentation)
18. Lee KH, Ho TS, Shen CF, Lin HC, Wang SM and Liu CC. Ciprofloxacin non-susceptible Streptococcus pyogenes isolates in southern Taiwan. 2010. The 204h Scientific Meeting of Taiwan Pediatric Association. Tainan, Taiwan. (Oral presentation)
19. Ho TS, Wang SM, Liu CC. Clinical and laboratory predictive markers of dengue Infection. 2011. The 2011 Annual Conference of the Infectious Diseases Society of Taiwan. Taoyuan, Taiwan. (Oral presentation)
20. Shen CF, Wang SM, Lee KS, Ho TS and Liu CC. Changes in the distribution of serotypes and clinical characteristics of invasive pneumococcal disease in children following the introduction of 7-valent pneumococcal vaccine (PCV7) at an university medical center in southern Taiwan. 2010. The 2010 Annual Scientific Meeting of the Infectious Disease Society of Taiwan. Taipei, Taiwan. (Oral presentation)
21. Ho TS, Wang SM, Yeh KC, Shen CF and Liu CC. The immune responses in healthcare workers before and after seasonal and novel swine-origin influenza A (H1N1) vaccination. 2011. The 206th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
22. Ho TS, Wang SM, Shen CF and Liu CC. Dynamic Changes in the Serum Concentrations of High Mobility Group Box-1 Peptide (HMGB1) during the Course of Acute Dengue Fever in Children. 2011. The 208th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
23. Ho TS, Wang SM, Shen CF and Liu CC. Proinflammatory mediators and immune responses in influenza virus infections. 2012. The 210th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
24. Ho TS, Wang SM, Huang MC, Shen CF, Hsu HC and Liu CC. Knowledge, attitude and perception of healthcare professionals to dengue diseases in Tainan City, Taiwan. 2012. The 210th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
25. Ho TS, Wang SM, Liu CC. Serum Concentration of High Mobility Group Box-1 Peptide Correlates Severity of Illness in Pediatric Dengue Infection. 2012. Singapore International Conference on Dengue and Emerging Infections (Poster presentation)
26. Ho TS, Wang SM, Cho YH, Wu CT, Ma YJ, Hsieh CC, Chuang CC, Chi CH, Wu JM, Liu CC. A Large outbreak of Scombroid fish poisoning associated with eating milkfish (Chanos chanos) at primary and middle schools in Tainan city, 2012. The 212th Scientific Meeting of Taiwan Pediatric Association. Taipei, Taiwan. (Oral presentation)
27. Ho TS, Wang SM, Wang LR, Liu CC. Measles seroprevalence and revaccination efficacy among healthcare workers. 2014. The 220th Scientific Meeting of Taiwan Pediatric Association. Kaohsiung, Taiwan. (Oral presentation)
28. Ho TS, Wang SM, Liu CC. Epidemiological trends of dengue infections in Taiwan. 2014. Cross-strait mini-symposium on dengue virus-Virus, host and immune response. Tainan, Taiwan. (invited speech)
29. Ho TS, Chuang YC, Yeh TM, Liu CC. Rapid Diagnostic Tests for Acute Dengue Infection. 2015. NUS-SSMB Mini Dengue symposium. Singapore. (invited speech)
30. Ho TS. Rapid Diagnostic Tests for Acute Dengue Infection. 2015. ini-Symposium on recent development on Dengue, Tainan, Taiwan. (invited speech)
31. Ho TS. Rapid Diagnostic Tests for Acute Dengue Infection. 2015. The 5th International Symposium on Infectious Disease and Signal Transduction, Tainan, Taiwan. (invited speech)
32. Ho TS, Lee H, Wang SM, Shen CF, Chang CP, Lin YS, Yeh TM, Liu CC. High-mobility group box 1 protein in pediatric dengue infection. 2015. 10th Asia-Pacific Congress of Medical Virology , Taipei, Taiwan. (Oral presentation)
33. Ho TS, Chuang YC, Yeh TM, Liu CC. A new rapid diagnostic test for acute dengue infection. 2015. 10th Asia-Pacific Congress of Medical Virology , Taipei, Taiwan. (Oral presentation)
34. Ho TS, Lee H, Wang SM, Shen CF, Chang CP, Lin YS, Yeh TM, Liu CC. High-mobility group box 1 protein in pediatric dengue infection. 2016. Annual Scientific Meeting of Pediatric Infectious Disease Society of Taiwan , Taipei, Taiwan. (Oral presentation)
35. Ho TS, Lee H, Wang SM, Shen CF, Chang CP, Lin YS, Yeh TM, Liu CC. High-mobility group box 1 protein in pediatric dengue infection. 2016. 8th Asian Congress of Pediatric Infectious Diseases. Bangkok, Thailand. (Best oral presentation award)
36. Ho TS, Chuang YC, Yeh TM, Wang SM, Shen CF, Lin YS, Liu CC. Clinical validation of a new rapid diagnostic test for acute dengue infection. 2017. 2nd Asia Dengue Summit (ADS 2017). Manilla, Philippines. (Oral presentation)
37. Ho TS, Lee H, Chung N, Kuo FC, Shen CF, Wang SM, Liu CC. Relationship between serum ferritin levels and disease severity in pediatric dengue infections. 2017. The 230th Scientific Meeting of Taiwan Pediatric Association, Taipei, Taiwan. (Oral presentation)
38. Ho TS. Applications and Implications of dengue rapid diagnostic tests. 2017. Asia Pacific Conference of emerging viral infections 2017, Colombo, Sri Lanka. (Invited speech)
39. Ho TS. Increasing recognition of dengue virus infection in children. The 231th Scientific Meeting of Taiwan Pediatric Association. 2017. Kaohsiung, Taiwan. (Invited speech)
40. Ho TS, Lai YC, Chuang YC, Shen CF, Wang SM,  Yeh TM, Liu CC. Development and clinical validation of diagnostic tests for dengue severity. The 236th Scientific Meeting of Taiwan Pediatric Association. 2018. Tainan, Taiwan. (Oral presentation)
41. Ho TS, Perng GC, Chang HC, Liu CC. Tools for Diagnosis of Mosquito-borne Viral Infections. 2019 Global Strategy on Control and Prevention of Mosquito-borne Viral Diseases. 2019. Tainan, Taiwan. (Invited speech)
42. Ho TS, Wang SM, Shen CF, Chang CP, Lin YS, Yeh TM, Liu CC. Viral nonstructural protein 1 promotes high mobility group box-1 intracellular translocation in acute dengue infection. 16th International Conference on Innate Immunity. 2019. Rhodes, Greece. (Poster presentation)
43. Ho TS. Engaging primary paediatricians effectively. The 13th Asia Pacific Hospice and Palliative Care Conference (APHC). 2019. Surabaya, Indonesia. (Invited speech)
 
(C) Patents:
1. 何宗憲、林隆豪、楊竹星、蘇芳慶、石紀。 輔助生理監測的肚兜與生理監測方法。 2016年 中華民國專利證書號碼: I538657，專利期限: 2016/06/01~2035/03/31
2. 何宗憲、莊詠鈞、許博智、鄭又瑋、劉清泉、葉才明。 評估個體之登革熱病毒感染嚴重程度的方法。 2018年 中華民國專利證書號碼: I624668，專利期限: 2018/05/21~2037/03/31
3. 郭志峯、曹妮娜、劉清泉、何宗憲、林以行、吳俊忠。A群鏈球菌感染之患者的分群方法。2018年 中華民國專利證書號碼: I643955，專利期限: 2018/12/01~2037/09/27
4. Kuo CF, Tsao NN, Liu CC, Ho TS.  2019. Method for treating infection of group A streptococcus. U.S. Patent No. 10345301B2.
 
(D) Book Chapters or Books:
1. 何宗憲、劉清泉。民國100年。〈流感概論〉，《流感疫苗教材手冊》, 第1-40頁，台北市：行政院衛生署疾病管制局。
2. Ho TS, Lin CF, Liu CC, Yeh TM, Anderson R, Lin YS. 2014. Lessons learned from dengue - focus on Taiwan. Chapter 3, pages 49-64, in " Dengue fever: transmission, diagnosis & surveillance", edited by Jamie Whitehorn and Jeremy Farrar, Future Medicine Ltd.
3. 何宗憲、劉清泉 (2016)〈登革熱的臨床特徵與處置〉，《登革熱的台灣經驗-科技部台灣重要新興感染症研究計畫成果報告》，第 89-104 頁，台北市：科技部台灣重要新興感染症研究計畫辦公室。
4. 何宗憲、齊嘉鈺 (2018) 〈小兒登革熱患者的臨床表徵〉，《台灣經驗登革熱防治手冊》，第 121-124 頁，苗栗縣竹南鎮：國家衛生研究院。
5. 何宗憲、王晴瑩、吳舜文（譯）（2019）《突破醫療溝通困境：醫護人員必修的一堂課》（原作者：Robert Buckman）。台北市：合記圖書出版社。

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